ABSTRACT
Objective: To determine the frequency of side branch [SB] occlusion during percutaneous coronary intervention [PCI] with stenting of bifurcation lesions and to assess the predictors of side branch occlusion in local population
Study Design: Cross-sectional study
Place and Duration of Study: Cardiac Catheterization Lab, Rawalpindi Institute of Cardiology, Rawalpindi, from July 2016 to January 2017
Methodology: A total of 200 patients fulfilling the inclusion criteria were included in the study with non-probability consecutive sampling technique. Variables like diameters and lesion lengths of main vessel and side branch were recorded using quantitative coronary analysis software [QCA]. The SB occlusion was defined as <3 TIMI score following main vessel PCI with stenting. The data was analysed using SPSS version 21.0
Results: Mean age [years] of the study population was 52.27 +/-13.33 including 180 [90.0%] male and 20 [10.0%] female patients. SB occlusion was observed in 15 [7.5%] of cases. Mean SB diameter was significantly larger in cases without SB occlusion than those with SB occlusion [2.06 +/-0.09 vs. 2.17 +/-0.26, p=0.003]. Similarly, SB lesions were significantly shorter in length in those without SB occlusion than those with SB occlusion [3.53 +/-0.51 and 4.66 +/-3.11, p<0.001]. However, mean MV diameter [mm] and mean MV lesions length [mm] in both the groups were statistically not significant
Conclusion: Mean SB diameter and lesion length are useful predictors of SB occlusion during stenting of bifurcation lesions in the local population
ABSTRACT
Objective: To determine the frequency of side branch [SB] occlusion during percutaneous coronary intervention [PCI] with stenting of bifurcation lesions and to assess the predictors of side branch occlusion in local population. Study Design: Cross-sectional study. Place and Duration of Study: Cardiac Catheterization Lab, Rawalpindi Institute of Cardiology, Rawalpindi, from July 2016 to January 2017
Methodology: A total of 200 patients fulfilling the inclusion criteria were included in the study with non-probability consecutive sampling technique. Variables like diameters and lesion lengths of main vessel and side branch were recorded using quantitative coronary analysis software [QCA]. The SB occlusion was defined as <3 TIMI score following main vessel PCI with stenting. The data was analysed using SPSS version 21.0
Results: Mean age [years] of the study population was 52.27 +/-13.33 including 180 [90.0%] male and 20 [10.0%] female patients. SB occlusion was observed in 15 [7.5%] of cases. Mean SB diameter was significantly larger in cases without SB occlusion than those with SB occlusion [2.06 +/-0.09 vs. 2.17 +/-0.26, p=0.003]. Similarly, SB lesions were significantly shorter in length in those without SB occlusion than those with SB occlusion [3.53 +/-0.51 and 4.66 +/-3.11, p<0.001]. However, mean MV diameter [mm] and mean MV lesions length [mm] in both the groups were statistically not significant
Conclusion: Mean SB diameter and lesion length are useful predictors of SB occlusion during stenting of bifurcation lesions in the local population
ABSTRACT
To identify the efficacy and side effects of Diacerein in patients with mild to moderate knee mteoarthritis. Quasi experimental study. Outpatient Department of Armed Forces Institute of Rehabilitation Medicine, Rawalpindi from June 2012 to June 2013. Ninety cases fulfilling American College of Rheumatology criteria for diagnosis of Knee Osteoarthritis and falling in Grades I-III of Kellgren-Lawrence Radiological Classification for Knee Osteoarthritis were included. Pre-treatment associated symptoms, complete blood count, renal and liver function tests were documented. After a baseline pain assessment on a 10-Point Visual Analogue Scale, 50 mg of Diacerein was given orally for 4 months followed by pain assessment and inquiry about adverse effects at 6[th] week, 3[rd] and 6[th] months. Post-treatment labs were repeated. Reduction in pain was analyzed by paired-sample t-test using SPSS version 17. Chi-Square test was used to assess the frequency of adverse effects. A p-value < 0.05 was considered sigruficant. Mean age was 61.5 +/- 7.8 years. Majority 77 [85.6%] were females. Mean Visual Analogue Scale at start was 6.1 +/- 0.87. Sigruficant pain reduction measured on Visual Analogue Scale was observed at six weeks [4.6 +/- 1.2] [p < 0.001], three months [2.37 +/- 0.91] [p < 0.001] and six months [2.2 +/- 0.85] [p < 0.001]. Very few patients developed diarrhea 3.3% and nausea 4.4%. Diacerein is effective drug with minimal side effects for treatment of mild to moderate painful Knee Osteoarthritis
Subject(s)
Humans , Male , Female , Osteoarthritis, Knee/drug therapyABSTRACT
Objective: To determine the diagnostic accuracy of antinuclear antibodies [ANA] and anti-double stranded DNA [dsDNA] antibodies in systemic lupus erythematosus patients presenting with dermatological features
Methods: In this cross-sectional study, 82 patients diagnosed as having systemic lupus erythematosus [SLE] per American College of Rheumatology [revised criteria 1997] from October 2012 to October 2013 and fulfilling the study's inclusion criteria were enrolled. These patients were first assessed by the dermatologist for four dermatological features, namely malar rash, discoid rash, photosensitivity and oral ulcers and were than referred to Department of Pathology for assessment of serological markers i.e. ANA and anti-dsDNA antibodies. The diagnostic accuracies of serological markers were analyzed to determine which one of the two serological markers is associated with any of the four dermatological features under observation in our study
Results: Out of 82 SLE patients, 77 [93.9%] patients were females and 5 [6.1 %] were males. Male to female ratio in this study was 1:15. Mean age of patients was 34.91 years and ranged between 8-62 years. Photosensitivity, malar rash, oral ulcers and discoid rash were found in 97.5%, 85.3%, 76.8% and 46.3% patients, respectively. ANA was not found to be statistically significantly associated with any of the dermatological features under observation in our study. However, anti-dsDNA antibodies were strongly associated with photosensitivity 0.024 [p<0.05] and malar rash was 0.003 [p<0.05]
Conclusion: The study proves that anti-dsDNA antibodies have high diagnostic accuracy for photosensitivity and malar rash in SLE patients and can be used alone with confidence in patients presenting with these two dermatological features, without burdening the lab with a lengthy serological evaluation